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Get emergency medical help if you have signs of an allergic reaction: hives; difficulty breathing; swelling of your face, lips, tongue, or throat.

Stop taking Kaletra and call your doctor at once if you have:

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• penis erection that is painful or lasts 4 hours or longer (if you take Kaletra with erectile dysfunction medication);

• muscle weakness, tired feeling, joint or muscle pain, feeling short of breath; or

• severe skin reaction--fever, sore throat, swelling in your face or tongue, burning in your eyes, skin pain followed by a red or purple skin rash that spreads (especially in the face or upper body) and causes blistering and peeling.

Kaletra may increase your risk of certain s or autoimmune disorders by changing the way your immune system works. Symptoms may occur weeks or months after you start treatment with Kaletra. Tell your doctor if you have:

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• swelling in your neck or throat (enlarged thyroid), menstrual changes, impotence, loss of interest in sex.

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